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"The Benefits of Mangosteen"


The Benefits of Mangosteen fruit have been known in southeast Asia for over 400 years.

Mangosteen is a small purple fruit about the size of a tangerine, which has traditionally been used to treat inflammation, dysentery, and skin disorders.

It was also used to fight infection by boiling up the fleshy part of the rind, also know as the pericarp, into a tea.

As early as 1855, a German scientist identified mangostin, a powerful antioxidant, known as a xanthone, which appeared to fight infection, fungus, bacteria, histamines and possibly cancer.


210 xanthones have been identified in nature, and over 40 of those have been found in the pericarp of the mangosteen fruit.


The significance of these xanthones can be better understood by reading about the relationship between antioxidants and free radicals in preventing damage to healthy cells and restoring health to areas that have all ready been damaged.


Benefits of Mangosteen Related to Healthy Exercise

I was just looking over the list of benefits and realized that I should make you aware of all the benefits of mangosteen in relationship to keeping your exercise healthy.

Did you know that you produce 20 to 30 times more free radicals when you exercise than when you are at rest?

It is the free radicals that cause all the cellular damage in our bodies that result in all the diseases and degenerative problems we develop during our life time.

Mangosteen contains so many antioxidants, that it has the potential to neutralize the free radicals. Then they are able to be flushed out of the body without doing damage.

For a more complete explanation of how to Stop Free Radical Damage click here.


The following is a list of some of the
Potential Benefits of Mangosteen.

Mangosteen MAY:

  • Slow aging
  • Fight bacterial infections
  • Prevent Alzheimer's
  • Improve symptoms of Parkinson's
  • Help with anxiety and depression
  • Help reduce allergy symptoms
  • Improve gum health and eye health
  • Reduce Migraines
  • Heal skin rashes
  • Reduce blood pressure
  • Energize
  • Reduce inflammation
  • Reduce pain
  • Reduce tumor formation
  • Reduce nerve pain
  • Lower fever
  • Lower cholesterol
  • Stimulate red blood cell growth
  • Help in the healing of stomach, mouth and bowel ulcers
  • Help fight viruses and infections
  • Support bone mass
  • Improve immune response
  • Help protect the heart
  • Help reduce the formation of cataracts
  • Reduce irritable bowel
  • Help fight fungus and parasites
  • Help support vascular health

So many of the Benefits of Mangosteen listed above deal with supporting Heart Disease Prevention including lowering cholesterol, lowering blood pressure, reducing inflammation, and supporting vascular health. If you would like more information here are some strategies from the Mayo Clinic





Research Abstracts

When I started writing this site a year ago, I could only find limited recent research in PubMed.com . Now I find 66 abstracts on Garcinia mangostana research, 9 of which are from 2008.

I will summarize a few here that look at specific benefits of mangosteen, but feel free to go to http://www.ncbi.nlm.nih.gov/sites/entrez for the complete listing and full abstracts.

So much is being studied about Mangosteen because it has so many powerful antioxidants that are showing some dramatic results. Here are just a few of the Abstracts.


1: Phytomedicine. 2005 Mar;12(3):203-8.Links Antibacterial activity of alpha-mangostin against vancomycin resistant Enterococci (VRE) and synergism with antibiotics. Sakagami Y, Iinuma M, Piyasena KG, Dharmaratne HR.

Osaka Prefectural Institute of Public Health, Osaka, Japan. sakagami@iph.pref.osaka.jp

"Alpha-Mangostin, isolated from the stem bark of Garcinia mangostana L., was found to be active against vancomycin resistant Enterococci (VRE) and methicillin resistant Staphylococcus aureus (MRSA), with MIC values of 6.25 and 6.25 to 12.5 microg/ml, respectively. Our studies showed synergism between alpha-mangostin and gentamicin (GM) against VRE, and alpha-mangostin and vancomycin hydrochloride (VCM) against MRSA. Further studies showed partial synergism between alpha-mangostin and commercially available antibiotics such as ampicillin and minocycline. These findings suggested that alpha-mangostin alone or in combination with GM against VRE and in combination with VCM against MRSA might be useful in controlling VRE and MRSA infections."



1: Exp Toxicol Pathol. 2008 Aug;60(4-5):357-64. Epub 2008 Apr 18.

Ameliorative prospective of alpha-mangostin, a xanthone derivative from Garcinia mangostana against beta-adrenergic cathecolamine-induced myocardial toxicity and anomalous cardiac TNF-alpha and COX-2 expressions in rats. Sampath PD, Vijayaragavan K.

Centre for Advanced Studies in Botany, University of Madras, Guindy Campus, Chennai, India.

"Altered membrane integrity and inflammation play a key role in cardiovascular damage. We investigated the salubrious effect of exogenously administered alpha-mangostin against beta-adrenergic cathecolamine-induced cardiovascular toxicity"... "Cardiac TNF-alpha and COX-2 expressions were significantly elevated in ISO-intoxicated rats. Pre-co-treatment with alpha-mangostin (200mg/kg body wt.) orally for 8 days significantly attenuated these abnormalities and restored the levels to near normalcy when compared to ISO intoxicated group of rats."

"In conclusion, alpha-mangostin preserves the myocardial membrane integrity and extenuates anomalous TNF-alpha and COX-2 expressions by mitigating ISO-induced oxidative stress and cellular damage effectively. Restoration of cellular normalcy accredits the cytoprotective role of alpha-mangostin."



1: Commun Agric Appl Biol Sci. 2007;72(3):431-41.Links Effects of alpha-mangostin from mangosteen pericarp extract and imidacloprid on Nilaparvata lugens (Stal.) and non-target organisms: toxicity and detoxification mechanism. Bullangpoti V, Visetson S, Milne J, Milne M, Sudthongkong C, Pronbanlualap S.

Dept. of Zoology, Faculty of Science, Kasetsart University, Bangkok 10900, Thailand.

"The brown planthopper, Nilaparvato lugens Stat. (BPH) is the most devastating insect pest in rice fields. Outbreaks of BPH, which are resistant to many synthetic insecticides, can cause total rice crop loss. This research was done to evaluate the efficiency of extracts of mangosteen pericarp (Garcina mangostana L.) as an alternative control of BPH Thailand strain..."

"The results from this research indicate that mangosteen pericarp extract can be an alternative insecticide for the control of BPH, which may possess high efficiency, cause with fewer environmental problems and result in less resistance in the BPH."


1: Food Chem Toxicol. 2008 Feb;46(2):688-93. Epub 2007 Sep 26.Click here to read Links Anti-inflammatory activity of mangostins from Garcinia mangostana. Chen LG, Yang LL, Wang CC.

Graduate Institute of Biomedical and Biopharmaceutical Sciences, College of Life Sciences, National Chiayi University, 300 University Road, Chiayi 600, Taiwan, ROC.

"The fruit hull of Garcinia mangostana Linn (Guttiferae) is used as an anti-inflammatory drug in Southeast Asia. Two xanthones, alpha- and gamma-mangostins, were isolated from the fruit hull of G. mangostana, and both significantly inhibited nitric oxide (NO) and PGE(2) production from lipopolysaccharide (LPS)-stimulated RAW 264.7 cells"...

"In an in vivo study, alpha-mangostin significantly inhibited mice carrageenan-induced paw edema. In conclusion, alpha- and gamma-mangostins from G. mangostana are bioactive substances with anti-inflammatory effects."


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